Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma

@article{Eckerle2009GeneEP,
  title={Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma},
  author={Susan Eckerle and Verena Brune and Claudia D{\"o}ring and Enrico Tiacci and Verena Bohle and Christer Sundstr{\"o}m and R. Kodet and Marco Paulli and Brunangelo Falini and Wolfram Klapper and Audrey S. Baur Chaubert and Klaus Willenbrock and Dirk Metzler and Andreas Braeuninger and Ralf K{\"u}ppers and M L Hansmann},
  journal={Leukemia},
  year={2009},
  volume={23},
  pages={2129-2138}
}
Anaplastic large cell lymphoma (ALCL) is a main type of T-cell lymphomas and comprises three distinct entities: systemic anaplastic lymphoma kinase (ALK) positive, systemic ALK− and cutaneous ALK− ALCL (cALCL). Little is known about their pathogenesis and their cellular origin, and morphological and immunophenotypical overlap exists between ALK− ALCL and classical Hodgkin lymphoma (cHL). We conducted gene expression profiling of microdissected lymphoma cells of five ALK+ and four ALK− systemic… CONTINUE READING
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Gene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK+ subtypes

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