Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis.

@article{Mariadason2005GeneEP,
  title={Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis.},
  author={John M. Mariadason and C. Nicholas and Kaitlin E L'Italien and Min Zhuang and Helena J M Smartt and Barbara G. Heerdt and Wancai Yang and Georgia A. Corner and Andrew G. Wilson and Lidija Klampfer and Diego Arango and Leonard H. Augenlicht},
  journal={Gastroenterology},
  year={2005},
  volume={128 4},
  pages={1081-8}
}
BACKGROUND & AIMS To define the genetic reprogramming that drives intestinal epithelial cell maturation along the crypt-villus axis, enterocytes were sequentially isolated from the villus tip to the crypts of mouse small intestine. METHODS Changes in gene expression were assessed using 27,405-element complementary DNA microarrays (14,685 unique genes) and specific changes validated by Western blotting. RESULTS A total of 1113 genes differentially expressed between the crypt and villus were… CONTINUE READING

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