Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain.

@article{Liu2004GeneEP,
  title={Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain.},
  author={Jianwen Liu and Joanne M. Lewohl and Peter Ronald Dodd and Patrick K. Randall and R. Adron Harris and R Dayne Mayfield},
  journal={Journal of neurochemistry},
  year={2004},
  volume={90 5},
  pages={1050-8}
}
Chronic alcohol exposure induces lasting behavioral changes, tolerance, and dependence. This results, at least partially, from neural adaptations at a cellular level. Previous genome-wide gene expression studies using pooled human brain samples showed that alcohol abuse causes widespread changes in the pattern of gene expression in the frontal and motor cortices of human brain. Because these studies used pooled samples, they could not determine variability between different individuals. In the… CONTINUE READING
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