Gene expression profiling of human oocytes following in vivo or in vitro maturation.

@article{Jones2008GeneEP,
  title={Gene expression profiling of human oocytes following in vivo or in vitro maturation.},
  author={Gayle M Jones and David S Cram and Bi Song and Maria Cristina Magli and Luca Gianaroli and Orly Lacham-Kaplan and Jock K. Findlay and Graham Jenkin and Alan O. Trounson},
  journal={Human reproduction},
  year={2008},
  volume={23 5},
  pages={1138-44}
}
BACKGROUND Immature human oocytes matured in vitro, particularly those from gonadotrophin stimulated ovaries, are developmentally incompetent when compared with oocytes matured in vivo. This developmental incompetence has been explained as poor oocyte cytoplasmic maturation without any determination of the likely molecular basis of this observation. METHODS Replicate whole human genome arrays were generated for immature and mature oocytes (matured in vivo and in vitro, prior to exposure to… CONTINUE READING

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