Gene expression profiling in naïve and vaccinated rainbow trout after Yersinia ruckeri infection: insights into the mechanisms of protection seen in vaccinated fish.

@article{Harun2011GeneEP,
  title={Gene expression profiling in na{\"i}ve and vaccinated rainbow trout after Yersinia ruckeri infection: insights into the mechanisms of protection seen in vaccinated fish.},
  author={Nor Omaima Harun and Tiehui Wang and Christopher J Secombes},
  journal={Vaccine},
  year={2011},
  volume={29 26},
  pages={4388-99}
}
Despite the importance and success of vaccination against bacterial diseases in fish, little is known about the mechanisms of vaccine-induced disease resistance. In this study a known efficacious bacterial vaccine, to Enteric Redmouth Disease (ERM), was used to vaccinate rainbow trout, and sixty days later the fish were challenged with the causative agent of the disease, Yersinia ruckeri. The bacterial burden in the spleen, the spleen index, and the expression profiles of pro- and anti… CONTINUE READING

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