Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.

@article{Mahoney2008GeneEP,
  title={Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.},
  author={Douglas J. Mahoney and Adeel Safdar and Gianni Parise and Simon Melov and Minghua Fu and Laura Macneil and Jakub Kaczor and Eric T Payne and Mark A Tarnopolsky},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={294 6},
  pages={R1901-10}
}
We used cDNA microarrays to screen for differentially expressed genes during recovery from exercise-induced muscle damage in humans. Male subjects (n = 4) performed 300 maximal eccentric contractions, and skeletal muscle biopsy samples were analyzed at 3 h and 48 h after exercise. In total, 113 genes increased 3 h postexercise, and 34 decreased. At 48 h postexercise, 59 genes increased and 29 decreased. On the basis of these data, we chose 19 gene changes and conducted secondary analyses using… CONTINUE READING