Gene expression profiling in breast cancer: classification, prognostication, and prediction.

@article{ReisFilho2011GeneEP,
  title={Gene expression profiling in breast cancer: classification, prognostication, and prediction.},
  author={Jorge S Reis-Filho and Lajos Pusztai},
  journal={Lancet},
  year={2011},
  volume={378 9805},
  pages={1812-23}
}
Microarray-based gene expression profiling has had a major effect on our understanding of breast cancer. Breast cancer is now perceived as a heterogeneous group of different diseases characterised by distinct molecular aberrations, rather than one disease with varying histological features and clinical behaviour. Gene expression profiling studies have shown that oestrogen-receptor (ER)-positive and ER-negative breast cancers are distinct diseases at the transcriptomic level, that additional… CONTINUE READING
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