Gene expression profiling in anti-CD11d mAb-treated spinal cord-injured rats.

@article{Gris2009GeneEP,
  title={Gene expression profiling in anti-CD11d mAb-treated spinal cord-injured rats.},
  author={Paul Gris and Allyson Tighe and Sakina G Thawer and Andrew Hemphill and Mark Oatway and Lynne Weaver and Gregory A. Dekaban and Arthur A. Brown},
  journal={Journal of neuroimmunology},
  year={2009},
  volume={209 1-2},
  pages={104-13}
}
Acute administration of a mononclonal antibody (mAb) raised against the CD11d subunit of the leukocyte CD11d/CD18 integrin after spinal cord injury (SCI) in the rat greatly improves neurological outcomes. We have profiled gene expression in anti-CD11d and isotyped-matched control mAb-treated rats after SCI. Microarray analysis demonstrated reduced expression of pro-inflammatory cytokines and increased expression of inflammatory mediators that promote wound healing and the expression of scar… CONTINUE READING