Gene expression profiling in T-cell acute lymphoblastic leukemia.

  title={Gene expression profiling in T-cell acute lymphoblastic leukemia.},
  author={Adolfo A. Ferrando and A Thomas Look},
  journal={Seminars in hematology},
  volume={40 4},
T-cell acute lymphoblastic leukemia (T-ALL) presents a difficult medical problem. T-ALL's clinical features and the biological properties of the leukemia cells are not predictive of prognosis, and thus have not been useful for risk-specific adjustments in therapeutic intensity. Microarray gene expression analyses of T-cell leukemic lymphoblasts have not only improved our understanding of the biological heterogeneity of this disease but have revealed clinically relevant molecular subtypes. Five… CONTINUE READING
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