Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase.

@article{Zemskova2006GeneEP,
  title={Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase.},
  author={Marina Zemskova and William J. Wechter and Svetlana Bashkirova and C. Chen and Robert Reiter and Michael B. Lilly},
  journal={Biochemical pharmacology},
  year={2006},
  volume={72 10},
  pages={1257-67}
}
We have used gene expression profiling to characterize genes regulated by the anti-tumor non-steroidal anti-inflammatory drug (NSAID)-like agent R-flurbiprofen (RFB) in murine TRAMP prostate cancer. Mice with spontaneous, palpable tumors were treated with RFB 25 mg/(kgd) x 7d orally, or vehicle only. RNA was then extracted from tumor tissue and used for… CONTINUE READING