Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22.

@article{Kim2010GeneEP,
  title={Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22.},
  author={Hyun-Ju Kim and Genevi{\`e}ve Morrow and J. Timothy Westwood and S{\'e}bastien Michaud and Robert M Tanguay},
  journal={Experimental gerontology},
  year={2010},
  volume={45 7-8},
  pages={611-20}
}
Aging is a complex process accompanied by a decreased capacity to tolerate and respond to various stresses. Heat shock proteins as part of cell defense mechanisms are up-regulated following stress. In Drosophila, the mitochondrial Hsp22 is preferentially up-regulated in aged flies. Its over-expression results in an extension of lifespan and an increased resistance to stress. Hsp22 has chaperone-like activity in vitro, but the mechanism(s) by which it increases lifespan in flies are unknown… CONTINUE READING