Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone

@article{Lee2008GeneEP,
  title={Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone},
  author={Cheng-Han Lee and Inigo Espinosa and Kristin C. Jensen and Subbaya Subramanian and Shirley X. Zhu and Sushama Varma and Kelli D. Montgomery and Torsten O. Nielsen and Matt van de Rijn and Robert B. West},
  journal={Modern Pathology},
  year={2008},
  volume={21},
  pages={531-539}
}
Giant cell tumor of the bone (GCTOB) is a primary bone tumor that occurs mainly in young adults and is capable of locally aggressive growth. Its histologic appearance can resemble a number of benign and malignant tumors but no useful diagnostic marker is known currently. To identify diagnostic markers for this tumor, global gene expression profiling using cDNA microarray was performed on 6 fresh-frozen GCTOB, 3 aneurysmal bone cysts, 4 fibrous dysplasias and 12 giant cell tumors of tendon… CONTINUE READING

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