Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells.

@article{Youns2009GeneEP,
  title={Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells.},
  author={Mahmoud A. Youns and Thomas H Efferth and Juergen Reichling and Kurt Fellenberg and Andrea Bauer and J{\"o}rg D. Hoheisel},
  journal={Biochemical pharmacology},
  year={2009},
  volume={78 3},
  pages={273-83}
}
Pancreatic cancer is one of the most aggressive human malignancies, with an extremely poor prognosis. The paucity of curative therapies has translated into an overall 5-year survival rate of less than 5%, underscoring a desperate need for new therapeutic options. Artesunate (ART), clinically used as anti-malarial agent, has recently revealed remarkable anti-tumor activity. However, the mechanisms underlying those activities in pancreatic cancer are not yet known. Here we evaluated the anti… CONTINUE READING