Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis.

RATIONALE Little is known about the genetic regulation of granulomatous inflammation in sarcoidosis. OBJECTIVES To determine if tissue gene array analysis would identify novel genes engaged in inflammation and lung remodeling in patients with sarcoidosis. METHODS Gene expression analysis was performed on tissues obtained from patients with sarcoidosis… (More)