Gene expression profiling identifies C/EBPdelta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation.

@article{Slofstra2007GeneEP,
  title={Gene expression profiling identifies C/EBPdelta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation.},
  author={Sjoukje H. Slofstra and Angelique P A Groot and Maartje H P Obdeijn and Pieter H. Reitsma and Hugo Ten Cate and C. Arnold Spek},
  journal={American journal of respiratory and critical care medicine},
  year={2007},
  volume={176 6},
  pages={602-9}
}
RATIONALE A runaway inflammatory response to systemic infection or severe trauma is characterized by the activation of a diversity of pathways, ultimately resulting in the development of disseminated intravascular coagulation (DIC) and multiorgan failure. OBJECTIVES Despite increased fundamental knowledge of the pathogenesis of DIC, the exact molecular mechanisms remain elusive. We aimed therefore to improve our understanding of the molecular pathways underlying endotoxin-induced DIC… CONTINUE READING
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