Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake.

@article{Anghel2010GeneEP,
  title={Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake.},
  author={Adrian Gabriel Anghel and Christina A. M. Jamieson and Xiaofeng Ren and James Young and R Porche and E Ozigbo and David E Ghods and Michael L. Lee and Y Liu and Kabirullah Lutfy and Theodore C Friedman},
  journal={Neuroscience},
  year={2010},
  volume={167 2},
  pages={554-66}
}
Addictive drugs including opioids activate signal transduction pathways that regulate gene expression in the brain. However, changes in CNS gene expression following morphine exposure are poorly understood. We determined changes in gene expression following short- and long-term morphine treatment in the hypothalamus and pituitary using genome-wide DNA microarray analysis and confirmed those alterations in gene expression by real-time reverse transcriptase polymerase chain reaction (RT-PCR… CONTINUE READING

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