Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma.

@article{Agnihotri2014GeneexpressionPE,
  title={Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma.},
  author={Sameer Agnihotri and Isabel Gugel and Marc Remke and Antje Bornemann and Georgios Pantazis and Stephen C Mack and David Shih and Sanjay K. Singh and Nesrin Sabha and Michael D. Taylor and Marcos Soares Tatagiba and Gelareh Mohammed Zadeh and Boris Krischek},
  journal={Journal of neurosurgery},
  year={2014},
  volume={121 6},
  pages={1434-45}
}
OBJECT Vestibular schwannomas (VS) are common benign tumors of the vestibular nerve that cause significant morbidity. The current treatment strategies for VS include surgery or radiation, with each treatment option having associated complications and side effects. The transcriptional landscape of schwannoma remains largely unknown. METHODS In this study the authors performed gene-expression profiling of 49 schwannomas and 7 normal control vestibular nerves to identify tumor-specific gene… CONTINUE READING
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