Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells.

@article{Lehtonen2007GeneEP,
  title={Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells.},
  author={Anne Lehtonen and Helena Ahlfors and Ville Veckman and Minja Miettinen and Riitta Lahesmaa and Ilkka Julkunen},
  journal={Journal of leukocyte biology},
  year={2007},
  volume={82 3},
  pages={710-20}
}
Macrophages and dendritic cells (DC) are APC, which regulate innate and adaptive immune responses. Macrophages function locally mainly, maintaining inflammatory responses in tissues, whereas DC take up microbes, mature, and migrate to local lymph nodes to present microbial antigens to naïve T cells to elicit microbe-specific immune responses. Blood monocytes can be differentiated in vitro to macrophages or DC by GM-CSF or GM-CSF + IL-4, respectively. In the present study, we performed global… CONTINUE READING

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