Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome.

@article{Jnsson2010GeneEP,
  title={Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome.},
  author={G{\"o}ran J{\"o}nsson and Christian Busch and Stian Knappskog and J{\"u}rgen Geisler and Hrvoje Mileti{\'c} and Markus Ringn{\'e}r and Johan Richard Lillehaug and {\AA}ke Borg and P E L{\o}nning},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 13},
  pages={
          3356-67
        }
}
PURPOSE The incidence of malignant melanoma is increasing worldwide in fair-skinned populations. Melanomas respond poorly to systemic therapy, and metastatic melanomas inevitably become fatal. Although spontaneous regression, likely due to immune defense activation, rarely occurs, we lack a biological rationale and predictive markers in selecting patients for immune therapy. EXPERIMENTAL DESIGN We performed unsupervised hierarchical clustering of global gene expression data from stage IV… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2009
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Predicting clinical outcome through molecular profiling in stage III melanoma.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2008
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Identification and characterization of a novel melanoma tumor suppressor gene on human chromosome 6q21.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2009
VIEW 1 EXCERPT