Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapy.

@article{Hartmann2005GeneEP,
  title={Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapy.},
  author={Lynn C. Hartmann and Karen H. Lu and Gerald P. Linette and William A. Cliby and Kimberly R. Kalli and David M. Gershenson and Robert C. Bast and James P. Stec and Natalia Iartchouk and David I. Smith and Jeffrey S. Ross and Sebastian Hoersch and Viji Shridhar and James Lillie and Scott H. Kaufmann and Edwin A. Clark and Andrew I Damokosh},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 6},
  pages={2149-55}
}
PURPOSE Women with advanced epithelial ovarian cancer are routinely treated with platinum-paclitaxel chemotherapy following cytoreductive surgery, yet only approximately 20% achieve long-term disease-free survival. We hypothesized that differences in gene expression before treatment could distinguish patients with short versus long time to recurrence after administration of platinum-paclitaxel combination chemotherapy. EXPERIMENTAL DESIGN To test this hypothesis, gene expression profiling of… CONTINUE READING
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