Gene expression profiles of primary breast tumors maintained in distant metastases.

  title={Gene expression profiles of primary breast tumors maintained in distant metastases.},
  author={Britta Weigelt and Annuska M. Glas and Lodewyk F. A. Wessels and Anke T. Witteveen and Johannes Leo Peterse and Laura van't Veer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 26},
It has been debated for decades how cancer cells acquire metastatic capability. It is unclear whether metastases are derived from distinct subpopulations of tumor cells within the primary site with higher metastatic potential, or whether they originate from a random fraction of tumor cells. Here we show, by gene expression profiling, that human primary breast tumors are strikingly similar to the distant metastases of the same patient. Unsupervised hierarchical clustering, multidimensional… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.
158 Citations
1 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 158 extracted citations


Publications referenced by this paper.

Ed Ic a L Sc Ie N Ce S

  • S. Gruvberger, M. Ringner, +6 authors P. S. Meltzer
  • Nat. Genet
  • 2001

Similar Papers

Loading similar papers…