Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease.

@article{Brooks2007GeneEP,
  title={Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease.},
  author={Wendy M Brooks and Patrick J. Lynch and Catherine C Ingle and Alexander Hatton and Piers C. Emson and Richard L. M. Faull and Mike P Starkey},
  journal={Brain research},
  year={2007},
  volume={1127 1},
  pages={127-35}
}
The successfully functioning brain is a heavy user of metabolic energy. Alzheimer's disease, in which cognitive faculties decline, may be due, at least in part, to metabolic insufficiency. Using microarray analysis and quantitative RT-PCR, the expression of mRNA transcripts involved in glucose metabolism was investigated in Alzheimer's diseased post-mortem human hippocampal samples. Of the 51 members of the glycolytic, tricarboxylic acid cycle, oxidative phosphorylation, and associated pathways… CONTINUE READING

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