Gene expression profiles of drug-metabolizing enzymes (DMEs) in rat liver during pregnancy and lactation.

@article{He2007GeneEP,
  title={Gene expression profiles of drug-metabolizing enzymes (DMEs) in rat liver during pregnancy and lactation.},
  author={Xi He and Hirofumi Yamauchi and Kazuhiko Suzuki and Masaki Ueno and Hiroyuki Nakayama and Kunio Doi},
  journal={Experimental and molecular pathology},
  year={2007},
  volume={83 3},
  pages={428-34}
}
A cDNA microarray analysis was conducted to examine hepatic gene expression profiles in pregnant and lactating F344 rats compared to a virgin control group using an Affymetrix GeneChip system. Of the approximately 16000 gene transcripts interrogated, more than 1000 were significantly modified in their expression when detected either in late pregnancy (19 days of gestation, GD 19, 513 genes upregulated and 579 downregulated) or on the day of delivery (postpartum 0 day, PPD 0, 497 upregulated and… CONTINUE READING

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