Gene expression profiles of bronchoalveolar cells in pulmonary TB.

  title={Gene expression profiles of bronchoalveolar cells in pulmonary TB.},
  author={B H V Ramakrishnan Raju and Yoshihiko Hoshino and Ilana Belitskaya-Levy and Rod Dawson and Stanley R Ress and Jeffrey Allen Gold and Rany Condos and Richard I. Pine and Stuart Z Brown and Anna Nolan and William Rom and Michael D. Weiden},
  volume={88 1},
The host response to Mycobacterium tuberculosis includes macrophage activation, inflammation with increased immune effector cells, tissue necrosis, and cavity formation, and fibrosis, distortion, and bronchiectasis. To evaluate the molecular basis of the immune response in the lungs of patients with active pulmonary tuberculosis (TB), we used bronchoalveolar lavage to obtain cells at the site of infection. Affymetrix GeneChip microarrays and cDNA nylon filter microarrays interrogated gene… CONTINUE READING


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