Gene expression profiles in mouse embryo fibroblasts lacking stathmin, a microtubule regulatory protein, reveal changes in the expression of genes contributing to cell motility

@article{Ringhoff2009GeneEP,
  title={Gene expression profiles in mouse embryo fibroblasts lacking stathmin, a microtubule regulatory protein, reveal changes in the expression of genes contributing to cell motility},
  author={Danielle N. Ringhoff and Lynne Cassimeris},
  journal={BMC Genomics},
  year={2009},
  volume={10},
  pages={343 - 343}
}
Stathmin (STMN1) protein functions to regulate assembly of the microtubule cytoskeleton by destabilizing microtubule polymers. Stathmin over-expression has been correlated with cancer stage progression, while stathmin depletion leads to death of some cancer cell lines in culture. In contrast, stathmin-null mice are viable with minor axonopathies and loss of innate fear response. Several stathmin binding partners, in addition to tubulin, have been shown to affect cell motility in culture. To… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Similar Papers

Loading similar papers…