Gene expression profiles in hepatitis C virus (HCV) and HIV coinfection: class prediction analyses before treatment predict the outcome of anti-HCV therapy among HIV-coinfected persons.

@article{Lempicki2006GeneEP,
  title={Gene expression profiles in hepatitis C virus (HCV) and HIV coinfection: class prediction analyses before treatment predict the outcome of anti-HCV therapy among HIV-coinfected persons.},
  author={Richard A. Lempicki and Michael A. Polis and Jun Yang and Mary T McLaughlin and Chad Koratich and Da Wei Huang and Brandie A Fullmer and Lynn Wu and Catherine Rehm and Henry Masur and H. Clifford Lane and Kenneth E Sherman and Anthony S. Fauci and Shyamasundaran Kottilil},
  journal={The Journal of infectious diseases},
  year={2006},
  volume={193 8},
  pages={1172-7}
}
Therapy for hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-infected patients results in modest cure rates. Gene expression patterns in peripheral blood mononuclear cells from 29 patients coinfected with HIV and HCV were used to predict virological response to therapy for HCV infection. Prediction analysis using pretherapy samples identified 79 genes that correctly classified all 10 patients who did not respond to therapy, 8 of 10 patients with a response at the end of… CONTINUE READING

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