Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice

@article{Chen2006GeneEP,
  title={Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice},
  author={Yefan Chen and Akio Kobayashi and Kin Ming Kwan and Randy L. Johnson and Richard R. Behringer},
  journal={BMC Nephrology},
  year={2006},
  volume={7},
  pages={1 - 1}
}
BACKGROUND Lim1 is a homeobox gene that is essential for nephrogenesis. During metanephric kidney development, Lim1 is expressed in the nephric duct, ureteric buds, and the induced metanephric mesenchyme. Conditional ablation of Lim1 in the metanephric mesenchyme blocks the formation of nephrons at the nephric vesicle stage, leading to the production of small, non-functional kidneys that lack nephrons. METHODS In the present study, we used Affymetrix probe arrays to screen for nephron… CONTINUE READING
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