Gene expression profiles in circulating tumor cells to predict prognosis in metastatic breast cancer patients.

@article{Mostert2015GeneEP,
  title={Gene expression profiles in circulating tumor cells to predict prognosis in metastatic breast cancer patients.},
  author={Bianca Mostert and Anieta M. Sieuwerts and J. K. Kraan and Joan B. Bolt-de Vries and Petra van der Spoel and Anne van Galen and Dieter J E Peeters and Luc Y Dirix and Caroline M. Seynaeve and Agnes Jager and Felix E. de Jongh and Paul Hamberg and Jacqueline M L Stouthard and Diederik F S Kehrer and Maxime P. Look and Maddalena Smid and Jan Willem C. Gratama and John A. Foekens and John W. M. Martens and Stefan Sleijfer},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2015},
  volume={26 3},
  pages={510-6}
}
BACKGROUND A circulating tumor cell (CTC) count is an established prognostic factor in metastatic breast cancer (MBC). Besides enumeration, CTC characterization promises to improve outcome prediction and treatment guidance. Having shown the feasibility of quantifying clinically relevant mRNA transcripts in CTCs, we determined the prognostic value of CTC gene expression in MBC. PATIENTS AND METHODS CTCs were isolated and enumerated from blood of 197 MBC patients who were about to start first… CONTINUE READING
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