Gene expression profiles in HPV‐infected head and neck cancer

  title={Gene expression profiles in HPV‐infected head and neck cancer},
  author={NF Schlecht and RD Burk and Leslie R. Adrien and Anne Dunne and Nicole Kawachi and Catherine Sarta and Q G Chen and Margaret Brandwein-Gensler and MB Prystowsky and Geoffrey J. Childs and R.V. Smith and TJ Belbin},
  journal={The Journal of Pathology},
Epidemiological and laboratory evidence indicate that, in addition to tobacco and alcohol, human papillomaviruses (HPV) play an important aetiological role in a subset of head and neck squamous cell carcinoma (HNSCC). To evaluate the molecular pathogenesis of HPV‐infected HNSCC, we compared gene expression patterns between HPV‐positive and ‐negative HNSCC tumours using cDNA microarrays. Tumour tissue was collected from 42 histologically confirmed HNSCC patients from an inner‐city area of New… 

Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma

Important criteria required to predict clinically active HPV infection are highlighted, new biological pathways implicated in HPV tumorigenesis are identified and the understanding of HPV‐HNSCC physiopathology is increased to develop new targets for therapy.

Genomic and epigenomic analysis of HPV positive and HPV negative head and neck squamous cell cancer

The findings reinforce the causal role of HPV in oropharyngeal cancer and indicate that therapeutic stratification according to somatic genomic changes, in addition to HPV status, could be the most appropriate future approach for these cancers.

Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma

The data establish that archival FFPE tissue is very suitable for this type of methylome analysis, and suggest that HPV modulates the HNSCC epigenome through hypermethylation of Polycomb repressive complex 2 target genes such as cadherins, which are implicated in tumor progression and metastasis.

Advances in Tumor Virology Role of HPV in Head and Neck Cancer

The experimental and epidemiological data provide robust evidence for a causal role in OPSCC, but the evidence for association of HPV with other HNSCC such as oral cavity or larynx is weak.

A Decade of Global mRNA and miRNA Profiling of HPV-Positive Cell Lines and Clinical Specimens

This review focuses mainly on HPV16, however reports from other HPV species are used as references and proposes an approach for future research to include more comprehensive miRNA-mRNA target correlation analysis and to apply systems biology/gene networks methodology.

HPV infection and integration in oropharyngeal squamous cell carcinomas

Present therapeutic HPV-targeting strategies are focused on, future directions for de-intensified treatment of HPV-positive HNSCC are discussed and the development and future use of new antiviral and immunomodulatory therapeutics are discussed.

A predictive transcriptomic signature of oropharyngeal cancer according to HPV16 status exclusively.

Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx.

Improved overall survival was largely restricted to HPV-driven OPSCCs, which were associated with increased levels of tumor-infiltrating lymphocytes compared with HPV- driven non-OPSCCs.

Virology and molecular pathogenesis of HPV (human papillomavirus)-associated oropharyngeal squamous cell carcinoma.

The present review summarizes the aetiology of HPV-positive (HPV+) OPSCC and provides a detailed overview of HPV virology and molecular pathogenesis relevant to infection of oropharyngeal tissues.



Gene Expression Differences Associated with Human Papillomavirus Status in Head and Neck Squamous Cell Carcinoma

Gene expression profiles of HPV+ and HPV− tumors were compared with further exploration of the biological effect of HPV in HNSCC to reveal the unique pathways in HPV+ tumors that may explain the different natural history and biological properties of these tumors.

Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas

Analysis of E6 mRNA expression by RT‐PCR or alternatively, semiquantitative analyses of the viral load, seem more reliable assays to assess HPV involvement in HNSCC than the very sensitive DNA PCR analyses used routinely.

Gene identification by cDNA arrays in HPV-positive cervical cancer.

11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours

It is hypothesised that HPV infection may represent an early event in the HNSCC carcinogenic process, thus suggesting a distinct molecular pathway, and lack the genetic alterations which are common in other tumours.

Transcriptional profiling of a human papillomavirus 33–positive squamous epithelial cell line which acquired a selective growth advantage after viral integration

Alterations in gene expression represent key events in carcinogenesis. We have studied HPV‐induced cervical carcinogenesis, using an HPV‐33‐positive cell line (UT‐DEC‐1) established from a low‐grade

Human papillomavirus seropositivity and risks of head and neck cancer

Antibodies to HPV‐16 E6 and/or E7 represent a more specific biomarker than anti‐HPV‐16 VLP of an HPV‐related HNC and may be useful in therapy targeted for HPV‐ related tumors.

Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model

Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer mortality worldwide. Recent reports have associated a subset of HNSCC with high-risk human papillomaviruses (HPVs),

Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx

HP status was identified as an independent prognostic factor in oral and oropharyngeal cancers and appeared to be gender‐specific, suggesting the need for further study of the interaction between HPV and gender on survival.

Human papillomavirus and Epstein-Barr virus infection, p53 expression, and cellular proliferation in laryngeal carcinoma.

Laryngeal carcinomas are aggressive neoplasms with controversial association with the human papillomavirus (HPV) and Epstein-Barr virus (EBV). So far, the impairment of p53 protein function and its