Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes.

@article{Planas2010GeneEP,
  title={Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes.},
  author={Raquel Planas and Jorge Carrillo and Alicia Mansilla Sanchez and M Carme Ruiz de Villa and Felipe N{\'u}{\~n}ez and Joan Verdaguer and Roger F. L. James and Ricardo Pujol-Borrell and Marta Vives-Pi},
  journal={Clinical and experimental immunology},
  year={2010},
  volume={159 1},
  pages={23-44}
}
Type 1 diabetes (T1D) is caused by the selective destruction of the insulin-producing beta cells of the pancreas by an autoimmune response. Due to ethical and practical difficulties, the features of the destructive process are known from a small number of observations, and transcriptomic data are remarkably missing. Here we report whole genome transcript analysis validated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and correlated with immunohistological… CONTINUE READING