Gene expression profiles associated with treatment response in oligodendrogliomas.

  title={Gene expression profiles associated with treatment response in oligodendrogliomas.},
  author={Pim J. French and Sigrid M. A. Swagemakers and Jord H. A. Nagel and Mathilde C. M. Kouwenhoven and Eric Brouwer and Peter J. van der Spek and Theo M. Luider and Johan M. Kros and Martin J. van den Bent and Peter A. E. Sillevis Smitt},
  journal={Cancer research},
  volume={65 24},
Oligodendrogliomas are a specific subtype of brain tumor of which the majority responds favorably to chemotherapy. In this study, we made use of expression profiling to identify chemosensitive oligodendroglial tumors. Correlation of expression profiles to loss of heterozygosity on 1p and 19q, common chromosomal aberrations associated with response to treatment, identified 376, 64, and 60 differentially expressed probe sets associated with loss of 1p, 19q or 1p, and 19q, respectively… CONTINUE READING


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