Gene expression profiles and phosphorylation patterns of AMP-activated protein kinase subunits in various mesenchymal cell types.

BACKGROUND Recent studies on bone have shown an endocrine role of the skeleton, which could be impaired in various human diseases, including osteoporosis, obesity, and diabetes-associated bone diseases. As a sensor and regulator of energy metabolism, AMP-activated protein kinase (AMPK) may also play an important role in the regulation of bone metabolism… CONTINUE READING