Gene expression profile of tissue engineered skin subjected to acute barrier disruption.

@article{Koria2003GeneEP,
  title={Gene expression profile of tissue engineered skin subjected to acute barrier disruption.},
  author={Piyush Koria and Daniel Brazeau and Keith Lough Kirkwood and Patrick M. Hayden and Mitchell E. Klausner and Stelios T Andreadis},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={121 2},
  pages={
          368-82
        }
}
The main function of the skin is to protect the body from infection, dehydration, and other environmental insults by creating an impermeable barrier of cornified cell layers, the stratum corneum. In contrast to cells in culture, tissue-engineered skin equivalents contain well-developed basal, spinous, granular, and cornified cell layers providing an excellent model to study the tissue response to barrier disruption. After 7 d of culture at the air-liquid interface the barrier of the tissues was… CONTINUE READING
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