Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin.

@article{Albertson2004GeneEP,
  title={Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin.},
  author={Dawn N Albertson and Barb Pruetz and Carl J. Schmidt and Donald M Kuhn and Gregory Kapatos and Michael J Bannon},
  journal={Journal of neurochemistry},
  year={2004},
  volume={88 5},
  pages={1211-9}
}
Chronic cocaine abuse induces long-term neural adaptations as a consequence of alterations in gene expression. This study was undertaken to identify those transcripts differentially regulated in the nucleus accumbens of human cocaine abusers. Affymetrix microarrays were used to measure transcript abundance in 10 cocaine abusers and 10 control subjects matched for age, race, sex, and brain pH. As expected, gene expression of cocaine- and amphetamine-regulated transcript (CART) was increased in… CONTINUE READING

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