Gene expression profile of butyrate-inhibited vascular smooth muscle cell proliferation

  title={Gene expression profile of butyrate-inhibited vascular smooth muscle cell proliferation},
  author={Kasturi Ranganna and Zivar Yousefipour and Frank M. Yatsu and Shirlette G. Milton and Barbara E. Hayes},
  journal={Molecular and Cellular Biochemistry},
Excessive proliferation of vascular smooth muscle cells (VSMCs) is a critical element in the development of several vascular pathologies, particularly in atherosclerosis and in restenosis due to angioplasty. We have shown that butyrate, a powerful antiproliferative agent, a strong promoter of cell differentiation and an inducer of apoptosis inhibits VSMC proliferation at physiological concentrations with no cytotoxicity. In the present study, we have used cDNA array technology to unravel the… CONTINUE READING
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