Gene expression profile changes correlating with radioresistance in human cell lines.

@article{Ishikawa2006GeneEP,
  title={Gene expression profile changes correlating with radioresistance in human cell lines.},
  author={Ken-ichi Ishikawa and Kumiko Koyama-Saegusa and Y. Otsuka and Atsuko Ishikawa and Seiko Kawai and Kaori Yasuda and Tomo Suga and Yuichi Michikawa and Masao Suzuki and Mayumi Iwakawa and Takashi Imai},
  journal={International journal of radiation oncology, biology, physics},
  year={2006},
  volume={65 1},
  pages={
          234-45
        }
}
PURPOSE To identify gene expression profiles specific to radioresistance of human cells. METHODS AND MATERIALS Global gene expression profiles of a total of 15 tumor and normal fibroblast cell lines were analyzed using DNA microarrays and statistical clustering methods. Initially, six of the cell lines were categorized into radioresistant (RG) or nonradioresistant (NRG) groups according to the radiation dose required to reduce their survival to 10% (D10). Genes for which expression was… CONTINUE READING
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