Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis

  title={Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis},
  author={Philip Gierer and Saleh Mohamed Ibrahim and Thomas Mittlmeier and Dirk Koczan and Steffen M{\"o}ller and J{\"u}rgen Landes and Georg Gradl and Brigitte Vollmar},
  journal={Arthritis Research & Therapy},
  pages={R868 - R876}
A better understanding of the initial mechanisms that lead to arthritic disease could facilitate development of improved therapeutic strategies. We characterized the synovial microcirculation of knee joints in susceptible mouse strains undergoing intradermal immunization with bovine collagen II in complete Freund's adjuvant to induce arthritis (i.e. collagen-induced arthritis [CIA]). Susceptible DBA1/J and collagen II T-cell receptor transgenic mice were compared with CIA-resistant FVB/NJ mice… CONTINUE READING


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