Gene expression profile analysis of genes in rat hippocampus from antidepressant treated rats using DNA microarray

@inproceedings{Lee2010GeneEP,
  title={Gene expression profile analysis of genes in rat hippocampus from antidepressant treated rats using DNA microarray},
  author={Jun-Ho Lee and Eunjung Ko and Youngeun Kim and Ji-Young Min and Jian Liu and Yangseok Kim and Minkyu Shin and Moochang Hong and Hyunsu Bae},
  booktitle={BMC Neuroscience},
  year={2010}
}
The molecular and biological mechanisms by which many antidepressants function are based on the monoamine depletion hypothesis. However, the entire cascade of mechanisms responsible for the therapeutic effect of antidepressants has not yet been elucidated. We used a genome-wide microarray system containing 30,000 clones to evaluate total RNA that had been isolated from the brains of treated rats to identify the genes involved in the therapeutic mechanisms of various antidepressants, a tricyclic… CONTINUE READING