Gene expression phenotypes for lipid metabolism and intramuscular fat in skeletal muscle of cattle.

@article{deJager2013GeneEP,
  title={Gene expression phenotypes for lipid metabolism and intramuscular fat in skeletal muscle of cattle.},
  author={Nadia de Jager and Nicholas James Hudson and Antonio Reverter and Ross Barnard and Linda M. Cafe and Paul L. Greenwood and Brian P. Dalrymple},
  journal={Journal of animal science},
  year={2013},
  volume={91 3},
  pages={
          1112-28
        }
}
Gene expression phenotypes were evaluated for intramuscular fat (IMF) in bovine skeletal muscle as an alternative to traditional estimates of IMF%. Gene expression data from a time course of LM development in high- and low-marbling Bos taurus cattle crosses were compared to identify genes involved in intramuscular adipocyte lipid metabolism with developmentally similar gene expression profiles. Three sets of genes were identified: triacylglyceride (TAG) synthesis and storage, fatty acid (FA… 
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A gene expression estimator of intramuscular fat percentage for use in both cattle and sheep
TLDR
The utility of a comparative approach to identify robust estimators of IMF% in the LM in cattle and sheep is demonstrated and a number of approaches to using gene expression to rank animals for IMF% within a single farm/treatment, or to estimate differences in IMF% between two farms/treatments are demonstrated.
Using muscle gene expression to estimate triacylglyceride deposition, and relative contributions of fatty acid synthesis and fatty acid import in intramuscular fat in cattle
TLDR
Increased de novo FA synthesis in intramuscular adipocytes appeared to contribute more than increased FA uptake from circulation to the additional TAG deposition in W×H compared with P×H cattle between 12 and 25 months (forage diet).
Longitudinal muscle gene expression patterns associated with differential intramuscular fat in cattle.
TLDR
Application of regulatory impact factor analysis, a network method for identifying causal effector molecules, suggests marbling roles for transcription factors previously implicated in liposarcoma (unconstrained fatty masses) and adipogenesis (CREBL2, SP1, STAT1) and (3) inflammation (ISGF3G, HOXB13, PML).
Intramuscular fat deposition in ruminants and pigs : A transcriptomics perspective 1
The genomics era has led to an explosion in the study of gene expression in production animals. Intramuscular fat (IMF) content (both high and low) and composition are major quality attributes of…
Iron Content Affects Lipogenic Gene Expression in the Muscle of Nelore Beef Cattle
TLDR
The results indicate metabolic pathways that are partially influenced by iron, contributing to a better understanding of its participation in skeletal muscle physiology, suggesting reduced lipogenic activities with lower iron content.
Transcriptome analysis of cattle muscle identifies potential markers for skeletal muscle growth rate and major cell types
TLDR
Gene sets and gene markers for the analysis of many of the major processes/cell populations contributing to muscle composition and growth have been proposed, enabling a consistent interpretation of gene expression datasets from cattle LM.
TRIENNIAL GROWTH AND DEVELOPMENT SYMPOSIUM: Intramuscular fat deposition in ruminants and pigs: A transcriptomics perspective.
The genomics era has led to an explosion in the study of gene expression in production animals. Intramuscular fat (IMF) content (both high and low) and composition are major quality attributes of…
TRIENNIAL GROWTH AND DEVELOPMENT SYMPOSIUM: Molecular mechanisms related to bovine intramuscular fat deposition in the longissimus muscle.
TLDR
It is demonstrated that lipid metabolism in LM tissues is crucial for IMF deposition, whereas lipid metabolismIn liver plays only a minor role, which may help to design nutritional or genetic methods to manipulate IMF deposition and to modify fatty acid composition in beef cattle.
Putative Regulatory Factors Associated with Intramuscular Fat Content
TLDR
RNA-seq analysis, gene set enrichment analysis, and co-expression network methods, such as partial correlation coefficient with information theory (PCIT), regulatory impact factor (RIF) and phenotypic impact factors (PIF) were utilized to better understand intramuscular adipogenesis.
Increased expression of thyroid hormone responsive protein (THRSP) is the result but not the cause of higher intramuscular fat content in cattle
TLDR
The data support the putative role of THR SP as transcriptional regulator and demonstrate that an increased expression of THRSP in M. longissimus is a consequence of but not the reason for a higher number of intramuscular adipocytes in cattle with enhanced IMF deposition.
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