Gene expression patterns in mouse cortical penumbra after focal ischemic brain injury and reperfusion.

@article{Sarabi2008GeneEP,
  title={Gene expression patterns in mouse cortical penumbra after focal ischemic brain injury and reperfusion.},
  author={Arezou S Sarabi and Hui Shen and Yun Wang and Barry J. Hoffer and Cristina M. B{\"a}ckman},
  journal={Journal of neuroscience research},
  year={2008},
  volume={86 13},
  pages={2912-24}
}
Ischemic stress in the brain causes acute and massive cell death in the targeted core area followed by a second phase of damage in the neighboring penumbra. The purpose of this study was to examine the global gene expression patterns in the penumbra, because the ischemic lesion in this region could be rescued by restoration of blood flow and other protective therapies. Adult C57Bl/6 mice were subjected to a 90-min middle cerebral artery occlusion (MCAO). Laser capture microdissection (LCM) was… CONTINUE READING
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