Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: a real-time PCR study.

@article{Bckman2006GeneEP,
  title={Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: a real-time PCR study.},
  author={Cristina M. B{\"a}ckman and Lufei Shan and Ya Jun Zhang and Barry J. Hoffer and Sherry Leonard and Juan C Troncoso and Paul Vonsatel and Andreas C. Tomac},
  journal={Molecular and cellular endocrinology},
  year={2006},
  volume={252 1-2},
  pages={160-6}
}
Glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor-beta superfamily, is a potent trophic factor for dopaminergic neurons of the ventral midbrain, which are known to degenerate during Parkinson's disease (PD). The neuroprotective, neurorestorative, and stimulatory properties of GDNF has prompted numerous suggestions that this trophic factor may be a potential therapeutic tool to treat PD, and it has also been widely speculated that altered GDNF… CONTINUE READING