Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia.

@article{Fine2004GeneEP,
  title={Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia.},
  author={Bernard M. Fine and Martin Stanulla and Martin Schrappe and Minh Tam Thien Ho and Susanne F Viehmann and Jochen Harbott and Linda M. Boxer},
  journal={Blood},
  year={2004},
  volume={103 3},
  pages={1043-9}
}
We obtained a global view of gene expression in both cell lines and pediatric acute lymphoblastic leukemia (ALL) samples that harbor one of several selected chromosomal abnormalities. When the cell lines were studied alone, we found that these chromosomal abnormalities were associated with the predominant variation in transcriptional programs across the set of cell lines studied. When cell lines and clinical samples were studied together, we found that each chromosomal abnormality (TEL/AML1… CONTINUE READING