Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma.

@article{Hoshino2001GeneEO,
  title={Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma.},
  author={Makoto Hoshino and Yoichi Nakamura and Qutayba A Hamid},
  journal={The Journal of allergy and clinical immunology},
  year={2001},
  volume={107 6},
  pages={1034-8}
}
BACKGROUND Angiogenesis is a feature of airway remodeling in bronchial asthma. The mechanism responsible for this angiogenesis is unknown. Vascular endothelial growth factor (VEGF) is a potent inducer of endothelial cells, which may contribute to chronic inflammation and angiogenesis. OBJECTIVE We sought to investigate the molecular mechanisms underlying increased vascularity, and we examined the mRNA expression of VEGF and its receptors (flt-1 and flk-1) within bronchial biopsy specimens… CONTINUE READING

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