Gene expression of liver-specific proteins in hepatocyte spheroids in primary culture.

@article{Tamura1995GeneEO,
  title={Gene expression of liver-specific proteins in hepatocyte spheroids in primary culture.},
  author={Takashi Tamura and Norio Koide and Hajime Hada and Hidenori Shiraha and Takao Tsuji},
  journal={Acta medica Okayama},
  year={1995},
  volume={49 3},
  pages={161-7}
}
Adult rat hepatocytes assemble to form multicellular spheroids under non-adherent environments such as immobilized chondroitin sulfate-proteoglycan in primary culture. Previously, we demonstrated that hepatocyte spheroids exhibited various differentiated structures as observed in the liver tissue. It was also shown that hepatocyte growth was highly suppressed and several differentiated functions, including albumin production and gluconeogenesis, were well preserved in spheroids. To investigate… CONTINUE READING

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