Gene expression of human T lymphocytes cell cycle: experimental and bioinformatic analysis.

@article{Giacomelli2006GeneEO,
  title={Gene expression of human T lymphocytes cell cycle: experimental and bioinformatic analysis.},
  author={Luca Giacomelli and Claudio Nicolini},
  journal={Journal of cellular biochemistry},
  year={2006},
  volume={99 5},
  pages={
          1326-33
        }
}
Human lymphocytes gene expression is monitored before and after PHA stimulation over 72 h, using DNA microarray technology. Results are then compared with our previous bioinformatics predictions, which identified six leader genes of highest importance in human T lymphocytes cell cycle. Experimental data are strikingly compatible with bioinformatic predictions of the specific role and interaction of PCNA, CDC2, and CCNA2 at all phases of the cell cycle and of CHEK1 in regulating DNA repair and… CONTINUE READING
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