Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice.

@article{Ishida2006GeneEO,
  title={Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice.},
  author={Yoshinari Ishida and Tatsunori Takayasu and Akihiko Kimura and Takahito Hayashi and Nobuyuku Kakimoto and Tomoko Miyashita and Toshikazu Kondo},
  journal={Legal medicine},
  year={2006},
  volume={8 2},
  pages={
          102-9
        }
}
It is well known that the intake of paraquat (PQ), an herbicide, causes severe lung injury at chronic phases. We examined the intrapulmonary gene expression of cytokines and growth factors after PQ administration. To induce lung injury, C57BL/6 mice were intraperitoneally injected twice a week with 20 mg/kg of PQ. Histopathologically, at the early phase, lots of alveolar spaces contained edematous fluid. At 3 weeks after PQ challenge, a marked thickening of the alveolar walls with the… CONTINUE READING

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