Gene expression of cytokines (TNF-α, IFN-γ), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus.

@article{Rana2012GeneEO,
  title={Gene expression of cytokines (TNF-α, IFN-γ), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus.},
  author={Anita Rana and Ranjana Walker Minz and Rajesh Aggarwal and Shashi Anand and Neelam Pasricha and Sukhminder Singh},
  journal={Lupus},
  year={2012},
  volume={21 10},
  pages={1105-12}
}
OBJECTIVE Paediatric systemic lupus erythematosus (pSLE) exhibits an aggressive clinical phenotype and severe complications commonly renal involvement. This could be reflective of the ongoing chronic pro-inflammatory cytokine milieu. We examined relative gene expression of tumour necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ) and serum levels of interleukin-17 (IL-17) and IL-23 and their association with SLEDAI (SLE disease activity index) score and organ manifestations in pSLE. METHODS… CONTINUE READING