Gene expression of (pro)renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure.

@article{Hirose2009GeneEO,
  title={Gene expression of (pro)renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure.},
  author={Takuo Hirose and Nobuyoshi Mori and Kazuhito Totsune and Ryo Morimoto and Takahiro Maejima and Takuya Kawamura and Hirohito Metoki and Kei Asayama and Masahiro Kikuya and Takayoshi Ohkubo and Masahiro Kohzuki and Kazuhiro Takahashi and Yutaka Imai},
  journal={Peptides},
  year={2009},
  volume={30 12},
  pages={2316-22}
}
Recent studies have revealed that (pro)renin receptor ((P)RR), a newly identified member of the renin-angiotensin system, was associated with organ damage in the kidney. However, there has been little information for (P)RR in hearts. To investigate the regulation of (P)RR in heart failure, we examined the expression of (P)RR in hearts and kidneys of rats with congestive heart failure (CHF) due to coronary ligation by quantitative RT-PCR and immunohistochemistry. Significantly increased levels… CONTINUE READING

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