Gene expression kinetics governs stimulus-specific decoration of the Salmonella outer membrane

@article{Hong2018GeneEK,
  title={Gene expression kinetics governs stimulus-specific decoration of the Salmonella outer membrane},
  author={Xinyu Hong and Hsuen-Li Chen and Eduardo A. Groisman},
  journal={Science Signaling},
  year={2018},
  volume={11}
}
Lipid A is the innermost component of the lipopolysaccharide (LPS) molecules that occupy the outer leaflet of the outer membrane in Gram-negative bacteria. Lipid A is recognized by the host immune system and targeted by cationic antimicrobial compounds. In Salmonella enterica serovar Typhimurium, the phosphates of lipid A are chemically modified by enzymes encoded by targets of the transcriptional regulator PmrA. These modifications increase resistance to the cationic peptide antibiotic… CONTINUE READING
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Regulated Assembly of LPS, Its Structural Alterations and Cellular Response to LPS Defects

  • International journal of molecular sciences
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