Gene expression in major depressive disorder

  title={Gene expression in major depressive disorder},
  author={Rick Jansen and Brenda W J H Penninx and Vered Madar and K Xia and Yuri Milaneschi and J J Hottenga and Anke R Hammerschlag and Aartjan T. F. Beekman and Nic J. A. van der Wee and Johannes H Smit and Andrew I. Brooks and Jay A. Tischfield and Danielle Posthuma and Robert Anton Schoevers and Gerard van Grootheest and Gonneke A H M Willemsen and Eco J de Geus and Dorret I. Boomsma and Fred A. Wright and Fei Zou and Wei Sun and Patrick F. Sullivan},
  journal={Molecular Psychiatry},
The search for genetic variants underlying major depressive disorder (MDD) has not yet provided firm leads to its underlying molecular biology. A complementary approach is to study gene expression in relation to MDD. We measured gene expression in peripheral blood from 1848 subjects from The Netherlands Study of Depression and Anxiety. Subjects were divided into current MDD (N=882), remitted MDD (N=635) and control (N=331) groups. MDD status and gene expression were measured again 2 years later… CONTINUE READING